Identifying Novel Immunodominant Epitopes within Human Parainfluenza Virus-3 Matrix Protein

Human Parainfluenza Virus-3 (HPIV3) is a common cause of severe respiratory illness in immunocompromised patients and has no approved antiviral therapies. Recent preclinical studies demonstrated T-cell recognition of HPIV3 viral proteins, and a phase I study adoptively transferring virus specific T cells (VSTs) targeting HPIV3 to patients following bone marrow transplantation is underway (NCT03180216). Hence, we sought to identify immunodominant...