DNA Methylation and Type 2 Diabetes: the Use of Mendelian Randomization to Assess Causality

This review summarises recent advances in the field of epigenetics in order to understand the aetiology of type 2 diabetes (T2D).DNA methylation at a number of loci has been shown to be robustly associated with T2D, including TXNIP, ABCG1, CPT1A, and SREBF1. However, due to the cross-sectional nature of many epidemiological studies and predominant analysis in samples derived from blood rather than disease relevant tissues, inferring causality is...