Diagnostic biomarkers of Alzheimer’s disease: A state-of-the-art review

In 2018, there was a recent shift towards a biological definition of Alzheimer's disease (AD), based on biomarkers measured in vivo even before the onset of clinical dementia symptoms. No single biomarker can by itself accurately diagnose AD. A combination of biomarkers assessed through imaging and cerebrospinal fluid (CSF) yields better diagnostic accuracy. Although amyloid PET imaging and CSF levels of amyloid and tau deposits are increasingly...