Newer perspective on the coupling between glucose-mediated signaling and β-cell functionality
Abstract
Insulin secretion by the pancreatic β-cells is elicited in response to elevated extracellular glucose concentration. In addition to triggering insulin secretion, glucose-induced signal regulates β-cell proliferation and survival. However, the molecular mechanism underlying the effects of glucose on the β-cell functionality still remains unclear. Glucokinase, a hexokinase isozyme that catalyzes the phosphorylation of glucose, acts as the glucose...
Paper Details
Title
Newer perspective on the coupling between glucose-mediated signaling and β-cell functionality
Published Date
Jan 1, 2020
Journal
Volume
67
Issue
1
Pages
1 - 8
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