T1 Meta-analysis of idiopathic pulmonary fibrosis genome-wide analyses identifies three novel genetic signals associated with disease susceptibility

Introduction

Idiopathic pulmonary fibrosis (IPF) is a devastating incurable lung disease. There have been three previous genome-wide association studies (GWAS) of IPF susceptibility. By combining these studies, we were able to perform the largest, densest and most powerful GWAS of IPF to date.

Methods

We used a two-stage approach. Stage 1 consisted of a genome-wide meta-analysis of IPF across the three previous studies....