Reconstitution of biosynthetic machinery of fungal natural products in heterologous hosts

Volume: 84, Issue: 3, Pages: 433 - 444
Published: Mar 3, 2020
Abstract
Ascomycota and basidiomycota fungi are prolific sources of biologically active natural products. Recent genomic data and bioinformatic analysis indicate that fungi possess a large number of biosynthetic gene clusters for bioactive natural products but more than 90% are silent. Heterologous expression in the filamentous fungi as hosts is one of the powerful tools to expression of the silent gene clusters. This review introduces recent studies on...
Paper Details
Title
Reconstitution of biosynthetic machinery of fungal natural products in heterologous hosts
Published Date
Mar 3, 2020
Volume
84
Issue
3
Pages
433 - 444
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