The Immunogenicity and Anti-tumor Efficacy of a Rationally Designed Neoantigen Vaccine for B16F10 Mouse Melanoma

Volume: 10
Published: Nov 5, 2019
Abstract
Tumor neoantigens are ideal targets for cancer immunotherapy as they are recognized by host immune system as foreigners and can elicit tumor-specific immune responses. However, existing strategies utilizing RNA or long peptides for the neoantigen vaccines render limited immune responses since only 20%-30% of neoantigens predicted in silico to bind MHC I molecules are capable of eliciting immune responses with the majority of neoantigen-specific...
Paper Details
Title
The Immunogenicity and Anti-tumor Efficacy of a Rationally Designed Neoantigen Vaccine for B16F10 Mouse Melanoma
Published Date
Nov 5, 2019
Volume
10
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