FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis
Abstract
During meiosis, telomere attachment to the inner nuclear envelope is required for proper pairing of homologous chromosomes and recombination. Here, we identified F-box protein 47 (FBXO47) as a regulator of the telomeric shelterin complex that is specifically expressed during meiotic prophase I. Knockout of Fbxo47 in mice leads to infertility in males. We found that the Fbxo47 deficient spermatocytes are unable to form a complete synaptonemal...
Paper Details
Title
FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis
Published Date
Nov 14, 2019
Journal
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