Impaired B-cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies
Abstract
A role for B cells in autoimmune diseases is now clearly established both in mouse models and humans by successful treatment of multiple sclerosis and rheumatoid arthritis with anti-CD20 monoclonal antibodies that eliminate B cells. However, the underlying mechanisms by which B cells promote the development of autoimmune diseases remain poorly understood. Here, we review evidence that patients with autoimmune disease suffer from defects in early...
Paper Details
Title
Impaired B-cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies
Published Date
Nov 12, 2019
Journal
Volume
292
Issue
1
Pages
90 - 101
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