Deletion of Smad3 prevents renal fibrosis and inflammation in type 2 diabetic nephropathy

Volume: 103, Pages: 154013 - 154013
Published: Feb 1, 2020
Abstract
null null Background null Transforming growth factor (TGF)-β/Smad3 signaling is highly activated in kidneys of patients with type 2 diabetic nephropathy (T2DN), however, the precise role of Smad3 in the pathogenesis of diabetic nephropathy remains unclear. null null null Methods null Smad3 knockout (KO)-db/db mice were generated by intercrossing of male and female double-heterozygous Smad3+/− db/m mice. Renal functions including urinary albumin...
Paper Details
Title
Deletion of Smad3 prevents renal fibrosis and inflammation in type 2 diabetic nephropathy
Published Date
Feb 1, 2020
Volume
103
Pages
154013 - 154013
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