The Circadian Clock Improves Fitness in the Fruit Fly, Drosophila melanogaster

It is assumed that a properly timed circadian clock enhances fitness, but only few studies have truly demonstrated this in animals. We raised each of the three classical Drosophila period mutants for >50 generations in the laboratory in competition with wildtype flies. The populations were either kept under a conventional 24-h day or under cycles that matched the mutant’s natural cycle, i.e. a 19-h day in the case of pers mutants and a 29-h day...