Polyvinylpyrrolidone composite nanofibers as efficient substrates for surface-assisted laser desorption/ionization mass spectrometry

A matrix-free laser desorption/ionization mass spectrometry (LDI-MS) approach was developed using electrospun composite nanofibers with controllable size, morphology and composition. Composite polyvinylpyrrolidone (PVP) nanofibers with added nanoparticles to enhance the absorption of laser energy absorber were studied. Fractal dimensional analysis was conducted to evaluate the electrospinning process for the first time, which provided useful...