METABOLOMICS PROFILING OF MUSCLE FAT DEPOSITION IN AGING: RESULTS FROM THE HEALTH ABC STUDY

Background: Age-related inter-muscular fat (IMF) deposition is associated with poor physical function in those with preserved/high muscle mass. However, the heterogeneity of IMF in aging is poorly understood. We used a semi-targeted metabolomics approach to: 1) determine the metabolites associated with IMF infiltration in aging; and 2) establish a model to predict IMF using the metabolome. Methods: We performed a cross-sectional analysis of 314...