Original paper

Arsenic Trioxide Abrogate MN1 Mediated RA-Resistance in Acute Promyelocytic Leukemia

Blood21.00
Volume: 134, Issue: Supplement_1, Pages: 5166 - 5166
Published: Nov 13, 2019
Abstract
Introduction: Described as a well know marker of worse prognosis in acute myeloid leukemia (AML), MN1 overexpression has been associated with inv(16) or EVI1 overexpression (Heuser et al., Blood 2007). The promoter region of the MN1 gene has Retinoic Acid Response Elements (RAREs), and higher levels of MN1 expression have been associated with decreased response to retinoic acid (RA) in vitro. Nevertheless, in the context of acute promyelocytic...
Paper Details
Title
Arsenic Trioxide Abrogate MN1 Mediated RA-Resistance in Acute Promyelocytic Leukemia
Published Date
Nov 13, 2019
Journal
Volume
134
Issue
Supplement_1
Pages
5166 - 5166
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