Melatonin for Rapid Eye Movement Sleep Behavior Disorder in Parkinson's disease: A Randomised Controlled Trial

Background Melatonin may reduce REM‐sleep behavior disorder (RBD) symptoms in Parkinson's disease (PD), though robust clinical trials are lacking. Objective To assess the efficacy of prolonged‐release (PR) melatonin for RBD in PD. Methods Randomized, double‐blind, placebo‐controlled, parallel‐group trial with an 8‐week intervention and 4‐week observation pre‐ and postintervention (ACTRN12613000648729). Thirty PD patients with rapid eye movement...