Endogenous T cells prevent tumor immune escape following adoptive T cell therapy
Volume: 129, Issue: 12, Pages: 5400 - 5410
Published: Nov 4, 2019
Abstract
While the outcome of adoptive T cell therapy (ACT) is typically correlated with the functionality of the inoculated T cells, the role of the endogenous T cells is unknown. The success of checkpoint blockade therapy has demonstrated the potentially curative value of preexisting tumor-primed T cells in cancer treatment. Given the results from checkpoint blockade therapy, we hypothesized that endogenous T cells contribute to long-term survival...
Paper Details
Title
Endogenous T cells prevent tumor immune escape following adoptive T cell therapy
Published Date
Nov 4, 2019
Volume
129
Issue
12
Pages
5400 - 5410
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