CSIG-17. SIGNALING PATHWAY-BASED CLUSTERING OF MASS CYTOMETRY DATA UNCOVERS CELLS ASSOCIATED WITH CLINICAL PROGRESSION IN GLIOBLASTOMA

Recent advances in single cell expression technology have allowed us to appreciate the complexity in tumoral heterogeneity of solid tumors such as glioblastoma (GBM), which remains uniformly fatal despite aggressive therapies. Currently, there is no knowledge about cell identities and functional characteristics of the different tumoral populations. To this end, we created a 28-marker mass cytometry panel composed of signaling markers, including...