Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats
Abstract
The aim of the present study was to determine the effect of sildenafil on dopamine, 5-hydroxyindol acetic acid (5-HIAA) and selected biomarkers of oxidative stress in the brain of hypoglycemic rats. The animals were treated intraperitoneally as follows: group 1 (control), saline solution; group 2, insulin (10 U per rat or 50 U kg-1); group 3, insulin + single dose of sildenafil (50 U kg-1 + 50 mg kg-1); group 4, insulin + three doses of...
Paper Details
Title
Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats
Published Date
Nov 1, 2019
Journal
Volume
70
Issue
1
Pages
121 - 127
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