Using single cell data to validate the cellular origins of a clonal expression biomarker in lung cancer

Background null Molecular biomarkers aim to stratify cancer patients into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical descriptors such as tumour stage. Transcriptomic intra-tumour heterogeneity (RNA-ITH) has been shown to confound existing expression-based biomarkers across multiple cancer types. null null null Methods null Here, we analyse multi-region whole-exome and RNA sequencing data for 156 tumour...