Myeloma Cells Addicted to Glutamine for Biomass Production Are Sensitive to Lenalidomide
Abstract
Introduction We have shown that in myeloma (MM) the immunomodulatory drugs (IMiDs) lenalidomide and pomalidomide, in a CRBN dependent fashion, inhibit thioredoxin reductase and thus increase intracellular oxidative stress as a consequence of peroxide accumulation (Sebastian et al. 2017). Accordingly, we have also shown that CRBN expression alone does not fully correlate with lenalidomide sensitivity, as the cells ability to decompose H2O2 is...
Paper Details
Title
Myeloma Cells Addicted to Glutamine for Biomass Production Are Sensitive to Lenalidomide
Published Date
Nov 13, 2019
Journal
Volume
134
Issue
Supplement_1
Pages
4410 - 4410
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