ACTR-70. A MULTISITE CLINICAL TRIAL OF SPECTROSCOPIC MRI-GUIDED RADIATION DOSE ESCALATION IN GLIOBLASTOMA PATIENTS

The standard of care for glioblastoma is neurosurgical resection followed by radiation therapy (RT) and temozolomide (TMZ) chemotherapy. Although RT is effective for glioblastoma, attempts to improve survival using RT dose escalation above 60 Gy have been largely unsuccessful. This may be because prior attempts have been targeted to resection cavity or enhancing tumor, which may not accurately predict areas at highest recurrence risk. To...