ATM activity in T cells is critical for immune surveillance of lymphoma in vivo

Volume: 34, Issue: 3, Pages: 771 - 786
Published: Nov 5, 2019
Abstract
The proximal DNA damage response kinase ATM is frequently inactivated in human malignancies. Germline mutations in the ATM gene cause Ataxia-telangiectasia (A-T), characterized by cerebellar ataxia and cancer predisposition. Whether ATM deficiency impacts on tumor initiation or also on the maintenance of the malignant state is unclear. Here, we show that Atm reactivation in initially Atm-deficient B- and T cell lymphomas induces tumor...
Paper Details
Title
ATM activity in T cells is critical for immune surveillance of lymphoma in vivo
Published Date
Nov 5, 2019
Journal
Volume
34
Issue
3
Pages
771 - 786
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