EP295 Investigating the effect of hypercapnia, hypoxia and pH on cellular proliferation in cervical cancer

Introduction/Background

In the phase III LACC cervical cancer trial, shorter disease-free survival and overall survival was observed in patients treated with minimally invasive radical hysterectomy in comparison to traditional open surgery. One hypothesis for this difference is an adverse effect of the prolonged exposure to the hypoxic, CO₂-rich, acidotic environment created during minimally invasive surgery. Greater cervical...