The Rho-associated kinase inhibitor fasudil can replace Y-27632 for use in human pluripotent stem cell research
Abstract
Poor survival of human pluripotent stem cells (hPSCs) following freezing, thawing, or passaging hinders the maintenance and differentiation of stem cells. Rho-associated kinases (ROCKs) play a crucial role in hPSC survival. To date, a typical ROCK inhibitor, Y-27632, has been the primary agent used in hPSC research. Here, we report that another ROCK inhibitor, fasudil, can be used as an alternative and is cheaper than Y-27632. It increased hPSC...
Paper Details
Title
The Rho-associated kinase inhibitor fasudil can replace Y-27632 for use in human pluripotent stem cell research
Published Date
May 12, 2020
Journal
Volume
15
Issue
5
Pages
e0233057 - e0233057
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