Benzoylaconitine Inhibits Production of IL-6 and IL-8 <i>via</i> MAPK, Akt, NF-κB Signaling in IL-1β-Induced Human Synovial Cells
Volume: 43, Issue: 2, Pages: 334 - 339
Published: Feb 1, 2020
Abstract
Benzoylaconitine (BAC), the main hydrolysate of aconitine, is a lower toxic monoester type alkaloid considered as the pharmacodynamic constituent in Aconitum species. In this study, the effects and mechanisms of BAC on production of inflammatory cytokines interleukin (IL)-6 and IL-8 were investigated in IL-1β-stimulated human synovial SW982 cells. The SW982 cells were incubated with BAC (0, 5 and 10 µM) before stimulating with IL-1β (10 ng/mL)....
Paper Details
Title
Benzoylaconitine Inhibits Production of IL-6 and IL-8 <i>via</i> MAPK, Akt, NF-κB Signaling in IL-1β-Induced Human Synovial Cells
Published Date
Feb 1, 2020
Volume
43
Issue
2
Pages
334 - 339
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