Clinical outcomes of mitral valve intervention in patients with mitral annular calcification: A systematic review and meta‐analysis

Background Mitral valve (MV) disease with mitral annular calcification (MAC) poses a surgical challenge and the clinical outcomes of MV surgery as well as transcatheter mitral valve replacement (TMVR) remain relatively unexplored. We performed a systematic review and meta-analysis to assess the effects of MAC on clinical outcomes following MV surgery and TMVR. Methods We searched MEDLINE and EMBASE databases until February 2019 for studies...