CD4 T cells in hepatitis B virus: “You don’t have to be cytotoxic to work here and help”

Understanding the immunopathogenesis of chronic hepatitis B (CHB) in full will be key to delivering the HBV cure program, allowing us to induce a range of host-leukocyte responses that act in concert to achieve complete viral elimination. While previous research has understandably focused on restoring the function of exhausted virus-specific CD8 T cells, there has been a relative lack of appreciation for the role played by the CD4 T cell pool...