Minocycline fails to improve neurologic and histologic outcome after ventricular fibrillation cardiac arrest in rats
Abstract
Prolonged cardiac arrest (CA) produces extensive neuronal death and microglial proliferation and activation resulting in neuro-cognitive disabilities. Among other potential mechanisms, microglia have been implicated as triggers of neuronal death after hypoxic-ischemic insults. Minocycline is neuroprotective in some brain ischemia models, either by blunting the microglial response or by a direct effect on neurons.To improve survival, attenuate...
Paper Details
Title
Minocycline fails to improve neurologic and histologic outcome after ventricular fibrillation cardiac arrest in rats
Published Date
Nov 19, 2019
Volume
8
Issue
7
Pages
106 - 119
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