Strengthening Causal Inference for Complex Disease Using Molecular Quantitative Trait Loci
Abstract
GWAS using large sample sizes have allowed the identification of many DNA sequence variants associated with molecular traits such as gene expression, DNA methylation, and protein levels that could be mediators between disease-associated genetic variants and the disease.Quantitative trait loci (QTLs), genetic variants influencing molecular traits, are increasingly used to identify causal features of complex traits.MR, a method using genetic...
Paper Details
Title
Strengthening Causal Inference for Complex Disease Using Molecular Quantitative Trait Loci
Published Date
Feb 1, 2020
Journal
Volume
26
Issue
2
Pages
232 - 241
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