Metabolic switching ofMycobacterium tuberculosisduring hypoxia is controlled by the virulence regulator PhoP

Published: Nov 16, 2019
Abstract
Mycobacterium tuberculosis (Mtb) retains the unique ability to establish an asymptomatic latent infection. A fundamental question in mycobacterial physiology is to understand the mechanisms involved in hypoxic stress, a critical player in persistence. Here, we show that the virulence regulator PhoP responds to hypoxia, the dormancy signal and effectively integrates hypoxia with nitrogen metabolism. We also provide evidence to demonstrate that...
Paper Details
Title
Metabolic switching ofMycobacterium tuberculosisduring hypoxia is controlled by the virulence regulator PhoP
Published Date
Nov 16, 2019
Journal
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