Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload
Abstract
Heterozygous mutations of the lysosomal enzyme glucocerebrosidase (GBA1) represent the major genetic risk for Parkinson's disease (PD), while homozygous GBA1 mutations cause Gaucher disease, a lysosomal storage disorder, which may involve severe neurodegeneration. We have previously demonstrated impaired autophagy and proteasomal degradation pathways and mitochondrial dysfunction in neurons from GBA1 knockout (gba1-/-) mice. We now show that...
Paper Details
Title
Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload
Published Date
Nov 4, 2019
Journal
Volume
27
Issue
5
Pages
1588 - 1603
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