Synergistic effect of IgG4 antibody and CTLs causes tissue inflammation in IgG4-related disease
Abstract
IgG4-related disease (IgG4-RD) is characterized by multi-organ irreversible damage resulting from tissue-specific infiltration of IgG4+ plasma cells and cytotoxic T lymphocytes (CTLs). However, whether IgG4 antibody contributes to the inflammation remains unclear. In this study, we established a mouse model that enabled us to evaluate the pathogenic function of IgG4 antibodies in response to a tissue-specific autoantigen using recombinant...
Paper Details
Title
Synergistic effect of IgG4 antibody and CTLs causes tissue inflammation in IgG4-related disease
Published Date
Nov 12, 2019
Journal
Volume
32
Issue
3
Pages
163 - 174
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