Functional genomics and gene-environment interaction highlight the complexity of congenital heart disease caused by Notch pathway variants

Volume: 29, Issue: 4, Pages: 566 - 579
Published: Dec 9, 2019
Abstract
Congenital heart disease (CHD) is the most common birth defect and brings with it significant mortality and morbidity. The application of exome and genome sequencing has greatly improved the rate of genetic diagnosis for CHD but the cause in the majority of cases remains uncertain. It is clear that genetics, as well as environmental influences, play roles in the aetiology of CHD. Here we address both these aspects of causation with respect to...
Paper Details
Title
Functional genomics and gene-environment interaction highlight the complexity of congenital heart disease caused by Notch pathway variants
Published Date
Dec 9, 2019
Volume
29
Issue
4
Pages
566 - 579
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