Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge
Abstract
Positron emission tomography (PET) enables non-invasive estimation of neurotransmitter fluctuations in the living human brain. While these methods have been applied to dopamine and some other transmitters, estimation of 5-hydroxytryptamine (5-HT; Serotonin) release has proved to be challenging. Here we demonstrate the utility of the novel 5-HT2A receptor agonist radioligand, [11C]CIMBI-36, and a d-amphetamine challenge to evaluate synaptic 5-HT...
Paper Details
Title
Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge
Published Date
Nov 12, 2019
Journal
Volume
45
Issue
5
Pages
804 - 810
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