pH‐controlled histone acetylation amplifies melanocyte differentiation downstream of MITF
Abstract
Tanning response and melanocyte differentiation are mediated by the central transcription factor MITF. This involves the rapid and selective induction of melanocyte maturation genes, while concomitantly the expression of other effector genes is maintained. In this study, using cell-based and zebrafish model systems, we report on a pH-mediated feed-forward mechanism of epigenetic regulation that enables selective amplification of the melanocyte...
Paper Details
Title
pH‐controlled histone acetylation amplifies melanocyte differentiation downstream of MITF
Published Date
Nov 11, 2019
Journal
Volume
21
Issue
1
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