Characterization of the prion protein binding properties of antisense oligonucleotides
Abstract
Antisense oligonucleotides (ASOs) designed to lower prion protein (PrP) expression in the brain through RNAse H1-mediated degradation of PrP RNA are in development as prion disease therapeutics. ASOs were previously reported to sequence-independently interact with PrP and inhibit prion accumulation in cell culture, yet in vivo studies using a new generation of ASOs found that only PrP-lowering sequences were effective at extending survival....
Paper Details
Title
Characterization of the prion protein binding properties of antisense oligonucleotides
Published Date
Nov 7, 2019
Journal
Pages
816868
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