Development and validation of a UPLC-MS method for determination of atazanavir sulfate by the “analytical quality by design” approach
Abstract
A UPLC-MS method for the estimation of atazanavir sulfate was developed using the “analytical quality by design” approach. The critical chromatographic quality attributes identified were retention time, theoretical plates and peak tailing. The critical method parameters established were percent of organic modifier, flow rate and injection volume. Optimization performed using Box-Behnken Design (BBD) established 10 % organic modifier, 0.4 mL min...
Paper Details
Title
Development and validation of a UPLC-MS method for determination of atazanavir sulfate by the “analytical quality by design” approach
Published Date
Nov 1, 2019
Journal
Volume
70
Issue
1
Pages
17 - 33
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