The beneficial effects of a muscarinic agonist on pancreatic β-cells
Abstract
The brain and nervous system play an important role in pancreatic β-cell function. This study investigated the role of muscarinic agonists or acetylcholine, which is the major neurotransmitter in the vagal nerve, in regulating pancreatic β-cell mass and glucose homeostasis. Administration of the muscarinic agonist bethanechol increased insulin secretion and improved glucose tolerance in insulin-receptor substrate 2 (IRS2)-knockout ( IRS-2 −/− )...
Paper Details
Title
The beneficial effects of a muscarinic agonist on pancreatic β-cells
Published Date
Nov 7, 2019
Journal
Volume
9
Issue
1
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