Insulin Action in the Hypothalamus Increases Second-Phase Insulin Secretion in Humans

<b><i>Background:</i></b> Animal studies and initial correlative data in humans indicate that insulin action in the brain may affect pancreatic insulin secretion. An important brain region for this process is the hypothalamus, an area that can develop insulin resistance. <b><i>Methods:</i></b> Fifteen young, healthy men (27 ± 3 years) with a wide BMI spectrum (20–30 kg/m²)...