Diabetes Type 2 and Kisspeptin: Central and Peripheral Sex-Specific Actions

Kisspeptin (KP) is a key molecule for the regulation of the hypothalamic–pituitary–gonadal axis and is also involved in the integration of metabolic cues to allow reproductive functions. KP systems are altered both centrally and peripherally in animal models of diabetes type 2 (DM2), which may account for both reproductive and metabolic dysfunctions in this disease. Alterations in the KP system appear to be sex and organ specific in rat models...