Impact of pulmonary disease on the prognosis in heart failure with preserved ejection fraction: the TOPCAT trial

Chronic obstructive pulmonary disease (COPD) is highly prevalent and predictive of worse outcomes in heart failure (HF) with preserved ejection fraction (HFpEF).1, 2 Severe COPD can result in cor pulmonale3 and worse outcomes in HF,2 while less severe obstructive lung disease is associated with impaired left ventricular filling and lower cardiac output despite preserved left ventricular ejection fraction (LVEF).4 We investigated the influence of...