Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function

As a cellular metabolic and stress sensor, the transcription factor Nrf2 is a pivotal regulator of stem cell self-renewal, proliferation, and differentiation.Nrf2 displays cell type-specific and/or stage-dependent impact on stem cell biology in response to various environmental cues.Nrf2 modulates PSCs through the regulation of pluripotency factors, metabolism, redox homeostasis, and cellular stress responses.Nrf2 maintain ASCs self-renewal,...