Sensitization of HT29 colorectal cancer cells to vemurafenib in three-dimensional collagen cultures.

Volume: 44, Issue: 2, Pages: 621 - 629
Published: Feb 1, 2020
Abstract
The extracellular matrix to which cancer cells adhere affects cellular sensitivity to anticancer drugs. We sought to examine the changes in sensitivity of colorectal cancer cells carrying the BRAF V600E mutation to vemurafenib cultured in three-dimensional (3D) collagen-I gels, while also identifying the signaling pathways involved in these changes. HT29 colorectal cancer cells were cultured in conventional tissue culture (TC) plastic plates or...
Paper Details
Title
Sensitization of HT29 colorectal cancer cells to vemurafenib in three-dimensional collagen cultures.
Published Date
Feb 1, 2020
Volume
44
Issue
2
Pages
621 - 629
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