Epigenetic and transcriptional mechanisms for the regulation of IL-10
Abstract
IL-10 is a critical immunoregulatory cytokine expressed in virtually all immune cell types. Maintaining a delicate balance between effective immune response and tolerance requires meticulous and dynamic control of IL-10 expression both epigenetically and transcriptionally. In this Review, we describe the epigenetic mechanisms controlling IL-10 expression, including chromatin remodeling, 3D chromatin loops, histone modification and DNA...
Paper Details
Title
Epigenetic and transcriptional mechanisms for the regulation of IL-10
Published Date
Aug 1, 2019
Journal
Volume
44
Pages
101324 - 101324
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