Challenges and Opportunities for Translation of Therapies to Improve Cognition in Down Syndrome

Volume: 26, Issue: 2, Pages: 150 - 169
Published: Feb 1, 2020
Abstract
Prenatal screening for Down syndrome (DS) creates unique opportunities for antenatal treatments to optimize neurocognitive development of affected individuals. Ts65Dn mice have been used in preclinical drug studies despite carrying three copies of genes that are non-orthologous to chromosome 21. Phenotypes in Ts65Dn and other mouse models of DS are significantly different from one another. Preclinical treatment studies have shown beneficial...
Paper Details
Title
Challenges and Opportunities for Translation of Therapies to Improve Cognition in Down Syndrome
Published Date
Feb 1, 2020
Volume
26
Issue
2
Pages
150 - 169
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