Re: The Obesity Paradox in COPD is Absent in US Never-Smokers.

Published on May 5, 2020in American Journal of Epidemiology4.473
· DOI :10.1093/AJE/KWZ244
Hailey R. Banack11
Estimated H-index: 11
(SUNY: State University of New York System),
Jay S. Kaufman64
Estimated H-index: 64
(McGill University),
Steven D. Stovitz19
Estimated H-index: 19
(UMN: University of Minnesota)
  • References (11)
  • Citations (1)
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: An obesity paradox in chronic obstructive pulmonary disease (COPD), whereby overweight/obese individuals have improved survival, has been well-described. These studies have generally included smokers. It is unknown whether the paradox exists in individuals with COPD arising from factors other than smoking. Nonsmoking COPD is understudied yet represents some 25%-45% of the disease worldwide. To determine whether the obesity paradox differs between ever- and never-smokers with COPD, 1,723 adult ...
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Smoking is often identified as a confounder of the obesity–mortality relationship. Selection bias can amplify the magnitude of an existing confounding bias. The objective of the present report is to demonstrate how confounding bias due to cigarette smoking is increased in the presence of collider stratification bias using an empirical example and directed acyclic graphs. The empirical example uses data from the Atherosclerosis Risk in Communities (ARIC) study, a prospective cohort study of 15,79...
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In a wide variety of disease states, obese persons have been shown to experience lower mortality and better survival than that shown by the nonobese. These states include diabetes,1–3 coronary artery disease,4,5 heart failure,6 peripheral arterial disease,5 hypertension,7 chronic obstructive pulmonary disease,8 lung cancer,9 and esophageal adenocarcinoma.10 Superior survival among the obese patients has also been demonstrated after myocardial infarction,11 coronary revascularization,12 and angio...
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Background: Obesity is associated with increased mortality in the general population but, paradoxically, with decreased mortality in persons with diabetes. Methods: Among 88,373 French women participating in the E3N-EPIC study who were free of diabetes in 1990, we estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) of mortality for body mass index (BMI) levels by diabetes status. Results: During an average 16.7 years of follow-up, 2421 cases of diabetes were identified and 3750 ...
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