Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts.

eLife7.70
Volume: 8
Published: Nov 1, 2019
Abstract
Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma, the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are not well elucidated. An epigenomic analysis of patient-derived and de-novo generated CAFs demonstrated widespread loss of cytosine methylation that was associated with overexpression of various inflammatory transcripts including CXCR4. Co-culture of neoplastic cells...
Paper Details
Title
Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts.
Published Date
Nov 1, 2019
Journal
Volume
8
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