Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells
Abstract
The mutagenic repair of Cas9 generated breaks is thought to predominantly rely on non-homologous end-joining (NHEJ), leading to insertions and deletions within DNA that culminate in gene knock-out (KO). In this study, by taking focused as well as genome-wide approaches, we show that this pathway is dispensable for the repair of such lesions. Genetic ablation of NHEJ is fully compensated for by alternative end joining (alt-EJ), in a...
Paper Details
Title
Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells
Published Date
Oct 31, 2019
Journal
Volume
9
Issue
1
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