Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses

Volume: 130, Issue: 2, Pages: 774 - 788
Published: Jan 6, 2020
Abstract
Efficacy of dendritic cell (DC) cancer vaccines is classically thought to depend on their antigen-presenting cell (APC) activity. Studies show, however, that DC vaccine priming of cytotoxic T lymphocytes (CTLs) requires the activity of endogenous DCs, suggesting that exogenous DCs stimulate antitumor immunity by transferring antigens (Ags) to endogenous DCs. Such Ag transfer functions are most commonly ascribed to monocytes, implying that...
Paper Details
Title
Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses
Published Date
Jan 6, 2020
Volume
130
Issue
2
Pages
774 - 788
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