Plasma Ceramide Species Are Associated with Diabetes Risk in Participants of the Strong Heart Study

Few studies have assessed the associations of ceramides and sphingomyelins (SMs) with diabetes in humans.We assessed associations of 15 circulating ceramides and SM species with incident diabetes in 2 studies.The analysis included 435 American-Indian participants from the Strong Heart Study (nested case-control design for analyses; mean age: 57 y; 34% male; median time until diabetes 4.3 y for cases) and 1902 participants from the Strong Heart...